I didn't think the first one made this worthy of a sequel, but I guess it made enough money and it's easy enough to make a sequel from. It's not like the story has to make much sense, its about inanimate objects coming to life, you can take it wherever you want to.
If this one made that much money, you can pretty much bank on there being another one coming in a few years.
They have a whole heap of museums wolrdwide they can choose from, maybe one of the wackier museums, like there's an "exotic" museum somewhere, I belive there is a cheese museum somewhere too, or one of the Ripleys museums. There's a UFO museum, that would make a good movie.